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We found that it was important to suppress EPO where blood stem cell expansion is desired and to restrict its expression to areas where red blood cell differentiation should occur.
The new findings on the essential role of Prox1 in satellite cell differentiation and slow muscle fiber type maintenance provide an important novel avenue for studies in muscle and metabolic diseases, such as type 2 diabetes.
He said the ability to control stem cell differentiation and function through microenvironment manipulation will have significant impact on the field of stem cell research.
It addresses the chemistry and cellular localization of polyamines; mechanisms of biosynthesis, their interconversion, and degradation in fungi, in comparison with animal and plant cells; polyamine distribution in the fungal kingdom as compared to other eukaryotic organisms; regulatory mechanisms of polyamine metabolism at the transcriptional, translational, and posttranslational levels in fungi and other organisms; general functions of polyamines, their possible modes of action, and their role in cell differentiation and morphogenesis in fungi and other organisms; and polyamine metabolism as a target for disease.
Purpose: A preliminary study found that neomangiferin inhibited splenic T cell differentiation into Th17 cells and promoted Treg cell production in vitro.
Researchers will focus on mechanisms and pathways of cell differentiation and control in embryonic development and on how drug treatment affects these mechanisms.
Wang's desire to better understand the epigenetic regulation of stem cell differentiation.
This means scientists can consistently maintain cell lines in the state they need them, either as pluripotent cells or during cell differentiation and transfection.
0, developed by Plasticell Limited, London, is a high-throughput platform that utilizes a cell culture technique for the discovery of stem cell differentiation protocols.
The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies.
A432) explores how researchers are tapping into the diverse cell differentiation capabilities of human stem cells to analyze numerous neurodevelopmental processes and how those processes are affected by environmental agents.
Topics include: molecular control of embryonic stem cell renewal, normal and cancer stem cell niches, therapeutic potential of mesenchymal stem cell differentiation, and cancer differentiating agents in stem cell-based therapy, among others.

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