94 adenocarcinoma CI: confidence interval; n: number; HE4: human epididymis 4; CA 125: cancer antigen
125 TABLE 4.
001 Malignant 304 (9-31792) Total 56 (4-31792) NA CA-125: cancer antigen
125; RMI: risk of malignancy index; SD: standard deviation; NA: non-applicable Table 4: Validity indicators of CA/125 and RMI in patients with malignant ovarian tumors and EOC, with and without borderline tumors (cut/off: CA/125 35 U/ml; RMI 200).
The granted United States Patent protects additional cancer antigens
which Cancer Vac can use in the commercialization of its immunotherapy program.
Synthesis and secretion of the ovarian cancer antigen
CA125 by the human cancer cell line NIH:OVCAR-3.
(CA) 125 is the only tumor marker for ovarian cancer that has been widely studied.
Our achievement of this milestone represents continued advancement of our lung cancer antigen
discovery program," said Steven Gillis, Ph.
Santa Monica, CA; 310-820-8029), a privately-held biotechnology company, announced a research collaboration, option and license agreement under which the parties will use Abgenix's human antibody technologies to discover and develop fully human monoclonal antibody therapies against selected cancer antigen
targets supplied by Agensys.
The urine marker prostate cancer antigen
3 (PCA3) has been shown to increase the specificity of PSA, especially for patients with repeat biopsies (11-13).
Gen-Probe claims its Progensa test, which screens urine samples for prostate cancer antigen
3, can better differentiate between malignancies and other conditions that create the false positives in the traditional PSA blood test.
At that point, virtually every potential breast cancer antigen
will be known or will be knowable," he noted.
The liposome enhances recognition of the cancer antigen
by the immune system and facilitates better delivery.
The company's core technology, called the Lm Technology, alters a live strain of Listeria monocytogenes (Lm) bacteria to generate cancer fighting T-cells directed against a cancer antigen
and neutralizing factors that protect the tumor microenvironment from immunologic attack and contribute to tumor growth.