Etoposide and camptothecin
were purchased from Hefei Bomei Biotechnology of China.
Overall, the antifungal activity of camptothecin
(20 [micro]M) and digitonin (80 [micro]M) were used as positive controls for apoptosis and necrosis, respectively (PC), and cells not treated with apigenin were used as negative controls (NC).
In this report, we successfully constructed a dual targeted nanodrug--hyaluronic acid nanoparticles encapsulated with camptothecin
(HANP/HCPT)--for effective therapy of cancer.
Endophytic fungi from Miquelia dentata Bedd., produce the anti-cancer alkaloid, camptothecin
. Phytomedicine 20, 337-342.
ex Arn (Icacinaceae) produce camptothecin
, 10hydroxycamptothecin and 9-methoxycamptothecin.
have shown that the extract, known as camptothecin
, has high antitumor properties.
CRLX101 is a nanoparticle-drug conjugate (NDC) designed to concentrate in tumors and slowly release its anti-cancer payload, camptothecin
, inside tumor cells.
It is important to mention that various antitumor drugs currently used, such as paclitaxel from the vinca alkaloids and camptothecin
were isolated from medicinal plants, which makes plant bioprospecting an important resource to be exploited in the search for new therapeutic approaches against cancer (Srivastava et al., 2005).
Cells were treated in complete growth media for 3 hr with [K.sub.2]Cr[O.sub.4] [Cr(VI)] and for 1 hr with camptothecin
Liu, "Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
," Cancer Research, vol.
However, the roles and regulatory mechanisms of HMGS genes in the biosynthesis of active constituents, including taxol, camptothecin
and tanshinones, need to be further investigated in medicinal plants.