References in periodicals archive ?
Lee, "Antitumor effects of camptothecin combined with conventional anticancer drugs on the cervical and uterine squamous cell carcinoma cell line SiHa," Korean Journal of Physiology and Pharmacology, vol.
With respect to mutant2 (A364T), the chemical compounds like Camptothecin, Ellipticine, Flavopiridol, Berberine, Daphnoretin showed better chemical interactions.
These approaches would also decrease our dependence on the natural resources and can provide sustainable supply of starting material for production of camptothecin.
It is suggested that Camptothecin interact with the enzyme /DNA complex through hydrogen bonds.
SN-38, the active metabolite of irinotecan, is widely used by many new drug companies to develop new camptothecin derivatives.
A poster entitled, "Evaluation of the efficacy of satraplatin (JM216) and its major metabolite JM118 in drug resistant cells and in combination with docetaxel" (Abstract #1387), reviewed the results of a study designed to explore the activity of satraplatin in several drug-resistant human tumor cell lines, including those resistant to taxanes, mitoxantrone, etoposide, camptothecin and cisplatin.
Irinotecan is a camptothecin, which acts primarily as a topoisomerase I inhibitor.
In 1994 AIDS Treatment News reported on a class of drugs being developed for cancer, but not for HIV, though some experts believed they should be tested as antiretrovirals (see Topotecan, CPT-11 (Irinotecan), Camptothecin, and Other Topoisomerase I Inhibitors, AIDS Treatment News #197, April 15, 1994).
Two important anti-cancer compounds were discovered at Research Triangle Institute (RTI) in the 1960s when Monroe Wall and Mansukh Wani isolated Taxol and Camptothecin from tree bark and recognized their unique cancer-fighting properties.
In preclinical animal studies, orally administered karenitecin has demonstrated excellent antitumor activity against common human solid tumors (including prostate, colon, breast, lung, melanoma and ovary) and superior potency against a variety of common human cancers compared to existing camptothecin derivatives.