List of Abbreviations IA-TXA: Intra-articular tranexamic acid PBL: Perioperative blood loss TKR: Total knee replacement BT: Blood transfusion THL: Total hemoglobin loss ETBL: Estimated total blood loss DV/kg: Drainage volume per kg Hb: Hemoglobin BMI: Body mass index TXA: Tranexamic acid OA: Osteoarthritis KL: Kellgren and Lawrence ROM: Range-of-motion ASA: American Society of Anesthesiologists aPTT: Activated partial prothrombin time INR: International normalized ratio
CrCl: Creatinine clearance CCI: Charlson Comorbidity Index.
FDA-approved labeling for prescription rantidine recommends a dose of 150 mg ranitidine orally every 24 hours for patients with a
CrCl less than 50 mL/minute, which coincides with the OTC labeled dose (GlaxoSmithKline, 2009).
So we recommend MDRD equation in preference to Cockcroft Gault's
CrCl equation to be used for estimation of GFR in clinical practice in young healthy Pakistani population.
Two hundred and twenty-seven (2.2%) of the 10 416 patients who had creatinine concentrations recorded at baseline started tenofovir despite a
CrCl <50 mL/min.
The GFR used to be estimated by
CrCl in 24-h urine but this is a time-consuming and imprecise method.
This would result in
Crcl values being higher leading to over estimation of GFR.
(47) The FBI is also a member of the Incident Coordination Communications Team managed by DHS
CRCL.
Choose: Tirofiban Dose: Bolus-Only Strategy: 0.25 mcg/kg, or Standard regimen: IV infusion of 0.4 [micro]g/kg/min for 30 min (reduce to 0.2 [micro]g/kg/min for
CrCl <30 mL/min), followed by IV infusion of 0.1 [micro]g/kg/min for 18-24 hours (reduce to 0.05 [micro]g/kg/ min if
CrCl <30 mL/min).
The phase III ROCKET AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) study compared rivaroxaban (20 mg od; 15 mg od in patients with
CrCl 30-49 mL/min) with dose-adjusted warfarin for stroke prevention in patients with nonvalvular atrial fibrillation [12].
Clinical findings of rheumatoid arthritis patients with pancytopenia due to methotrexate Case Age/ Treatment MTX Drugs Risk factors gender duration weekly (years) dosage (mg) 1 60/F 1 7.5 Not reported
CrCl <50 ml/min Hypoalbuminemia Dehydration Infection 2 59/M 1 15 Digoxin Infection
CrCl Furosemide <50 ml/min Dipyridamole Indomethacin 3 71/F 5 10 MTX Diclofenac
CrCl <50 Clopidogrel ml/min Old age Hypoalbuminemia Dehydration Infection Daily MTX High MCV value Case Bone marrow Peripheral findings eosinophil increase (days after admission) 1 Relative increase in 4th eosinphil, and dyserythropoiesis 2 Bone marrow 1st eosinophilia (40%), and dyserythropoiesis 3 Bone marrow 5th eosinophilia (50%) Case numbers 1 and 2 show results from the study by Bruyn et al.
Adequate renal function defined as a calculated Creatinine Clearance (
CrCl) greater than 60 ml/min as estimated by the Cockcroft- Gault equation
Creatinine clearance (
CrCl) has been the most widely used measure of GFR and requires the complete timed collection of urine as well as a blood sample for S-Cr (taken during the urine collection period).
