Chronic myeloid leukaemia (
CML) is a myeloproliferative disorder predominantly of adult life, having a male preponderance.1 These patients have variable presentations.2 Some are completely asymptomatic, their disease being diagnosed incidentally on routine blood CP while others may have symptoms due to anemia or splenomegaly.3
CML is usually diagnosed on peripheral blood film but the detection of the BCR-ABL fusion transcript by molecular techniques is necessary for establishing a definitive diagnosis.4
Correlation between Serum
CML, sRAGE Concentration, CML/sRAGE Ratio, and Clinical Parameters
Further Capex Cuts:
CML's pre-dividend FCF margin should expand to over 10% in 2018 as capex decreases.
Ninety two adult patients suffering from chronic-phase
CML who had been on Imatinib treatment for at least 6 months were included in the study.
Our case is a unique presentation of
CML blast crisis, which unfortunately has an aggressive biology.
It is evident that clinical management of patients suffering from
CML has been radically reformed, especially since the introduction of TKIs to inhibit BCR-ABL.
Reasonable amount of data is available regarding the epidemiology, molecular pathogenesis, clinical manifestations, and treatment response of secondary AML and MDS; however, very little is known about therapy-related
CML. Therapy-related
CML cannot be distinguished from de novo cases both cytogenetically and clinically.
The genetic alteration in
CML is one of the most extensively studied and best understood models in human cancer, and the treatment of
CML with tyrosine kinase inhibitors has been one of the most successful stories in oncology.
Total 83 patients with
CML were divided in to chronic phase (CP) 62 (74.6%), 17 (20.4%) in the accelerated phase (AP) and 3 (5.0%) in blast crisis (BC).
CML III does not address behavioral-based interview questions, nor does it have an extensive section on technology.
The brans significantly decreased levels of
CML compared to the control.
Bone marrow and peripheral blood samples from a total of 145 diagnosed cases of
CML were collected.
