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Related to CFTR: cystic fibrosis, CFTRI


The two-character ISO 3166 country code for CENTRAL AFRICAN REPUBLIC.


1. On a bond transaction table, an abbreviation indicating that a bond has matured, but is still trading.

2. ISO 3166-1 alpha-2 code for the Central African Republic. This is the code used in international transactions to and from Central African bank accounts.

3. ISO 3166-2 geocode for the Central African Republic. This is used as an international standard for shipping to the Central African Republic. The capital and each prefecture have their own codes with the prefix "CF." For example, the code for the Prefecture of Ouaka is ISO 3166-2:CF-UK.


Used in bond transaction tables in newspapers to indicate that the certificate of a bond has matured but is still trading: VarCp 10s99cf.
References in periodicals archive ?
It has also been showed that whenever M470V polymorphism comes along with another polymorphism mutation that leads to less activation of CFTR protein function (8, 35).
The objective of this study was to evaluate our AmpliSeq custom assay (PCR-based target enrichment followed by massively parallel sequencing on the PGM) for detecting inherited CFTR mutations in the clinical laboratory setting.
CFTR expression has previously been localised to the apical membrane of the corneal endothelium, (31,33,54) where it is known to facilitate fluid efflux in order to maintain corneal transparency.
CFTR details: defective HC03/chloride exchanger Genetic in pancreatic ductal apical membrane AP indicates acute pancreatitis; FRCP, endoscopic retrograde cholangiopancreatography.
Partial CFTR gene sequencing is also available for families with known mutations not detectable in a general screening assay.
Inhibitors of both PDE3 and PDE4 have been shown to elevate intracellular cAMP and activate CFTR in various airway epithelial models, suggesting they could serve as potential therapeutic targets for CF.
Importantly, acebilustat should be complementary to existing CF therapies, including the new CFTR modulators, and may actually help boost their efficacy by reducing the pool of neutrophil elastase enzyme in the lungs that can degrade functional CFTR in these patients.
Since the CFTR gene discovery, hundreds of mutations have been identified, including G551D, which results in a protein that disrupts the ion channel function of the cystic fibrosis protein.
They found that people exposed to cigarette smoke had a 60 percent decrease in CFTR activity, compared to those exposed only to clean air.
Its pathophysiology is due to dysfunctional regulation of chloride ion channels precipitated by mutations in the CFTR [cystic fibrosis transmembrane conductance regulator (ATP-binding cassette subfamily C, member 7)] gene (OMIM *602421).
The CFTR gene encodes a protein that regulates chloride transport.