If bone loss
continues in this population, however, the risk of fractures later in life might be increased.
ACE-011 is being jointly developed by Acceleron and Celgene Corporation for the treatment of cancer-related bone loss
Data from the current study suggest that bone loss
may be arrested by intra-articular corticosteroid injections more effectively in periarticular regions than in the whole hand," the researchers wrote.
These data provide evidence that inflammatory processes may be involved in some of the adaptation to microgravity and suggest that reducing NFI*B activation could serve as a countermeasure to bone loss
Average Rates of Trabecular and Cortical Bone Loss
per Year Rate in Rate in Fast Losers Slow Losers Trabecular bone of radius 6.
With the help of treadmill exercise countermeasure, the research team was able to prevent bone loss
in important skeletal regions.
At 1-year follow-up, only baseline FSH level was significantly related to bone loss
While GILZ is induced by glucocorticoids, directly overexpressing the protein appears to better target sources of bone loss
and inflammation and avoid these serious side effects.
In this study, researchers first determined whether mice that were induced with experimental arthritis also manifested bone loss
in the alveolar (tooth socket) bone.
The long term consequences of this substantial bone loss
are unclear but it might put them at increased risk of fracture or breaking a bone," said Elaine Yu, endocrinologist at Massachusetts General Hospital, Boston in the US.
In women, due to the normal process of aging and loss of oestrogen, normal bone loss
takes place; in women smokers, bone loss
is more rapid.
Understanding bone loss
associated with microgravity can help researchers understand the mechanisms of bone loss
in a wide range of disorders.