The

binomial model for the FLU concentrations accounted for types, hormone, types x hormone as fixed effects, and the populations as random effect.

LR test refers to the likelihood ratio test against a regular negative

binomial model of the same specification without facility-level random intercepts.

When fitting the negative

binomial model, the same specifications regarding the systematic component and the log link function were maintained; although, increased as shown in equation (3):

binomial model, the basic hypothesis is the possibility of creating a portfolio equivalent to the option, consisting partly of units of the underlying and partly of risk-free bonds.

However, in the negative

binomial model, the dispersion parameter is sufficiently close to 1, therefore providing adequate fit for the data.

For the first secondary efficacy endpoint, there was a 37% reduction in the frequency of PEs over the 48-week treatment period in the Apulmiq treatment group as compared to the placebo group (negative

binomial model; RR: 0.63; 95% CI: 0.48-0.82).

It means that once it is assured that the increasing values of X are associated with the increasing values of Y (from 0-1 in the

binomial model or from 1-3 in the trinomial model), the models accepted shall have a positive sign of the parameter's estimate for the X variable.

This one-period

binomial model is obviously a simplistic version of reality, assuming only two outcomes.

The general valuation principle is highlighted using a gold mine investment as an example and the

binomial model as the option pricing technique.

While the traditional option is valued using the

Binomial Model, the averaging process and the additional constraints on the holder's ability to exercise the option necessitates the use of Monte Carlo simulation to determine the EMOP's value.

During the Roundtable's teleconference (see "Data Collection" sidebar), one participant said his audit firm discouraged the company from using the

binomial model, as the auditors were concerned about their ability to effectively audit the results.