The collateral damage of the metalloproteinase/toxicity-removal process is the degraded fragments of ECM constituents such as hyaluronic acid, teanscin-c, decorin, biglycan
, and aggrecan.
(23) in a study on human pancreatic carcinoma cells observed that DPI (a pharmacological inhibitor of Noxs) suppressed TGF-[beta]-induced biglycan
expression and p38 activation.
Immunohistochemical localization of the proteoglycans decorin, biglycan
and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scars.
MMPs are active at neutral pH and can therefore catalyze the normal turnover of extracellular matrix (ECM) macromolecules such as interstitial and basement membrane collagens, proteoglycans such as aggrecan, decorin, biglycan
, fibromodulin, and versican, as well as accessory ECM proteins such as fibronectin.
The data available was for the 7 SLRP proteins that were found to be downregulated in the high PWV patients, namely, lumican, mimecan, prolargin, asporin, podocan, decorin, and biglycan
We recently assessed the expression and prognostic relevance of six immunohistochemical markers (Ki67, p53, biglycan
(BGN), receptor for hyaluronan-mediated motility (RHAMM), and insulin-like growth factor II mRNA binding protein 3 (IMP3)) in urachal adenocarcinomas.
(iii) Expression of tendon specific ECM (type I collagen, type III collagen, decorin, tenascin-C, and biglycan
) was significantly higher at 14 days in the nanoyarn group.
These include the subgroup lecticans (comprising aggrecan, brevican, versican, and neurocan), small leucine-rich proteoglycans (including biglycan
and decorin), phosphacan/ receptor-type-protein-tyrosine phosphatase [beta] (RPTP[beta]), and other proteoglycans, including NG2 and neuroglycanC .
, a kind of leucine-rich repeat proteoglycan, can also activate NLRP3 inflammasomes through interaction with TLR2/4 and purine P2X4/P2X7 receptors on macrophages .
Kiss et al., "The matrix component biglycan
is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages," The Journal of Clinical Investigation, vol.
Studies of cartilage explants report decreases in the density of glycosaminoglycan within the proteoglycan molecule, decreases in aggrecan molecule size and density, and increases in cartilage matrix degradation products such as low molecular weight hyaluronic acid and biglycan
(7) In trigger finger tendons, collagen type 1A1 and 3A1, aggrecan, and biglycan
are up-regulated, while metalloproteinase inhibitor 3 (TIMP-3) and matrix metallopeptidase (3) (MMP-3) are down-regulated, a situation also described in Achilles tendinosis.