in the vpn form a major part of the 5-HT-like immunoreactive (5-HT-LIR) plexus on the pedal sole.
A related Table 1 error is the description of the afferent axon
"class" that innervates these Golgi receptors.
Schwann cells have no place to migrant, the axons
have no scaffold on which to regenerate across the nerve gap, and there is no neurological recovery (68, 77, 78, 81-83, 132-135).
The differential expression of receptors or receptor complexes on the growth cone and their ligand-dependent interactions, along with some intracellular adaptors and mediators, link the external guidance cues with the internal environment of the axon
and result in the specificity and polarity of particular axons
To date, the primary focus of spinal cord regeneration has been directed towards getting the axons
to grow across the damaged part of the cord.
The pale areas of fibrosis that were observed on light microscopy corresponded to regions of active demyelination, as indicated by accumulations of myelin debris and the presence of large-diameter axons
that were devoid of myelin sheaths (figure 3).
The peripheral nerves converge on the spinal cord from the skin, muscles, and glands as 31 pairs of spinal nerves, each of which contains both sensory and motor axons
. Just before entering the cord, the spinal nerves split into their sensory and motor components.
They are well known to stimulate axon
regeneration by making proteins that promote nerve growth either on contact, or at a distance (by secreting growth factors).
Our lack of knowledge has been largely because of the shear technical difficulty of analyzing RNA and protein in the separate cell bodies and axons
. But this knowledge is critical to understanding ALS, because it turns out that proteins that bind and transport RNA in motor neurons, including a protein called FUS, can be mutated in ALS.
In subsequent studies using rats with spinal cord injuries, the researchers found that rat NPCs and human iPSC-derived NSCs implanted at the injury site both extended greater numbers of axons
through adult central nervous system white matter than through gray matter, and preferentially associated with rat host myelin.
, the long projections of neurons that transmit stimuli or signals to other cells, are affected in the case of injury and need to regrow to recover their function.
are in effect the primary transmission lines of the nervous system, and as bundles, they help make up nerves.