Management of atypical glandular cells
and adenocarcinoma in situ.
The utility of human papillomavirus testing in young women with atypical glandular cells
on Pap test.
NILM: negative for intraepithelial lesion and malignancy; ASC-US: atypical squamous cells of undetermined significance; ASC-H: atypical squamous cells, cannot exclude high-grade lesion; LSIL: low-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; AG: atypical glandular cells
; AG-NOS: atypical glandular cells
not otherwise specified.
Abnormal cervical cytology distribution Cytology result Frequency Percent ASC-H 5 3 ASCUS 103 62 Atypical glandular cells
6 4 HGSIL 8 5 LGSIL 44 27 Total 166 100 Table 3.
found approximately one-third of women with a diagnosis of atypical glandular cells
of endometrial origin had a significant uterine lesion on subsequent biopsy and suggested that Patients with a diagnosis of atypical endometrial cells on cervicovaginal smears should be followed closely, and endometrial curettage or biopsy should be included in their initial work-up.
AGC-US: Atypical Glandular Cells
of Undetermined Significance.
Key words: atypical glandular cells
, squamous intraepithelial lesions, endocervical curettage, colposcopy.
Human Papilloma Virus, Atypical Glandular Cells
, cervical smear.
Finally, the Cleveland Clinic Foundation presented a study concluding that ThinPrep Imager assisted screening "effectively detected atypical glandular cells
in Pap tests from patients with adenocarcinoma involving the cervix.
Out of 27 cases of epithelial cell abnormality are of atypical squamous cells of undetermined significance (ASCUS) (17), atypical glandular cells
of undetermined significance (AGCUS) (1), low-grade squamous intraepithelial lesion (LSIL) (2), high-grade squamous intraepithelial lesion (HSIL) (2) and invasive carcinoma cervix (5).
We assigned a stepwise discordance score in those cases that had a Pap test within 5 years of tissue diagnosis: a score of 0 was assigned for atypical glandular cells
(AGC)-favor neoplasia and above or for cytology specimens called high-grade SIL (HSIL) if histologic HSIL (cervical intraepithelial neoplasia 2/3) was also present in the tissue biopsy, a score of 1 was assigned for AGC not otherwise specified or if the cytology specimen was called HSIL and histologic HSIL was not present in the tissue biopsy, a score of 2 was given for cytology samples called low-grade SIL (LSIL), a score of 3 for ASCUS, and a score of 4 for negative for intraepithelial lesion or malignancy (NILM).
Adhere to 2006 ASCCP guidelines for the management of women who have a cytologic finding of atypical glandular cells