Thus it was important to examine the indirect immunotoxic effects of PRN exposure on the antigen processing
and presentation component of cell-mediated immunity.
org/cgi/content/abstract/65/17/7926 entitled "Restoration of the Expression of Transporters Associated with Antigen Processing
in Lung Carcinoma Increases Tumor-Specific Immune Responses and Survival", describes the use of AdhTAP1, an adenovirus containing TAP1 cDNA, to increase the immune response and survival in animal models of lung cancer.
org/cgi/content/abstract/65/16/7485, entitled Identification of Mechanisms Underlying Transporter Associated with Antigen Processing
(TAP) Deficiency in Metastatic Murine Carcinomas describes several novel aspects of TAP deficiencies in tumors.
The proprietary adenovirus construct has been optimized to allow enhanced expression of the Transporter of Antigen Processing
(TAP) that, in animal models, has been shown to increase both the killing of tumours by the immune system and animal survival.
The latest strategies that have emerged are to modulate immuno- surveillance, antigen processing
This allows the Ii-key/epitope 'hybrid' to bypass all the normal MHC class II antigen processing
controls and exploit any MHC class II molecule that it comes in contact with, forcing it to present the therapeutic antigenic epitope.