Thus it was important to examine the indirect immunotoxic effects of PRN exposure on the
antigen processing and presentation component of cell-mediated immunity.
org/cgi/content/abstract/65/17/7926 entitled "Restoration of the Expression of Transporters Associated with
Antigen Processing in Lung Carcinoma Increases Tumor-Specific Immune Responses and Survival", describes the use of AdhTAP1, an adenovirus containing TAP1 cDNA, to increase the immune response and survival in animal models of lung cancer.
org/cgi/content/abstract/65/16/7485, entitled Identification of Mechanisms Underlying Transporter Associated with
Antigen Processing (TAP) Deficiency in Metastatic Murine Carcinomas describes several novel aspects of TAP deficiencies in tumors.
The proprietary adenovirus construct has been optimized to allow enhanced expression of the Transporter of
Antigen Processing (TAP) that, in animal models, has been shown to increase both the killing of tumours by the immune system and animal survival.
The latest strategies that have emerged are to modulate immuno- surveillance,
antigen processing and presentation.
This allows the Ii-key/epitope 'hybrid' to bypass all the normal MHC class II
antigen processing controls and exploit any MHC class II molecule that it comes in contact with, forcing it to present the therapeutic antigenic epitope.
