Tampe, "Functional dissection of the transmembrane domains of the transporter associated with antigen processing
(TAP)," Journal of Biological Chemistry, vol.
and presentation defects have been implicated as the basis for impaired cell-mediated immunity induced by viruses (Fruh et al.
The spleen is a major site of immune cell interactions and antigen processing
, with active processes that contribute to the overall immune status [27, 28].
At this busy intersection between the endocytic and biosynthetic pathways, lies the late endosomal compartment, responsible for protein degradation and antigen processing
. In dendritic and other immune cells, this major constituent of the perinuclear cloud serves as a hub for MHC class II antigen loading.
It is involved in the promotion of tumor cell invasion (2), antigen processing
and turnover of intracellular and secreted proteins (3).
The results showed that DNA vaccines combining strategies that enhance MHC class I and II antigen processing
with SPI-6 have potential clinical implications for control of viral infection and neoplasia (34).
Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing
rather than peptide-MHC interactions.
Tumor-specific antigens (TSAs), called as neoantigens, are created by the genomic codon alternations, editing, usage, antigen processing
, and presentation [4, 5].
T-cell epitope immunogenicity is contingent on three basic steps: (i) antigen processing
, (ii) peptide binding to MHC molecules, and (iii) recognition by a cognate TCR.
In 2005, the role of CD1e in lipid antigen processing
was demonstrated by the identification of CD1e as a cofactor for a-mannosidase, a lysosomal enzyme that in the presence of CD1e degrades complex nonimmunogenic mycobacterial lipids to antigenic forms .
In conclusion our data demonstrate that targeting of antigens to CD206 on moDCs and CD89 on monocytes can lead to antigen processing
and presentation via HLADR to T-cells, in a specific and dose-dependent fashion.