Tampe, "Functional dissection of the transmembrane domains of the transporter associated with
antigen processing (TAP)," Journal of Biological Chemistry, vol.
Antigen processing and presentation defects have been implicated as the basis for impaired cell-mediated immunity induced by viruses (Fruh et al.
The spleen is a major site of immune cell interactions and
antigen processing, with active processes that contribute to the overall immune status [27, 28].
At this busy intersection between the endocytic and biosynthetic pathways, lies the late endosomal compartment, responsible for protein degradation and
antigen processing. In dendritic and other immune cells, this major constituent of the perinuclear cloud serves as a hub for MHC class II antigen loading.
It is involved in the promotion of tumor cell invasion (2),
antigen processing and turnover of intracellular and secreted proteins (3).
The results showed that DNA vaccines combining strategies that enhance MHC class I and II
antigen processing with SPI-6 have potential clinical implications for control of viral infection and neoplasia (34).
Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect
antigen processing rather than peptide-MHC interactions.
Tumor-specific antigens (TSAs), called as neoantigens, are created by the genomic codon alternations, editing, usage,
antigen processing, and presentation [4, 5].
T-cell epitope immunogenicity is contingent on three basic steps: (i)
antigen processing, (ii) peptide binding to MHC molecules, and (iii) recognition by a cognate TCR.
In 2005, the role of CD1e in lipid
antigen processing was demonstrated by the identification of CD1e as a cofactor for a-mannosidase, a lysosomal enzyme that in the presence of CD1e degrades complex nonimmunogenic mycobacterial lipids to antigenic forms [8].
In conclusion our data demonstrate that targeting of antigens to CD206 on moDCs and CD89 on monocytes can lead to
antigen processing and presentation via HLADR to T-cells, in a specific and dose-dependent fashion.
