Crystal structure of a complex between anthrax toxin
and its host cell receptor.
The combined anthrax toxin
protein plus chemotherapy has durable, anti-tumour effects worthy of further exploration.
Pentelute and his team have revised the anthrax toxin
to replace one of the toxic proteins with an antibody mimic that targets chronic myeloid leukemia cells.
Therecentcaseofpneumonia caused by B cereus producing anthrax toxins
occurred in a welder, which has been reported previously in other cases in Texas and Louisiana.
The first aim of the partnership is to assess the combination of one of IDRI's adjuvant compounds that has been shown to improve the generation of high tier neutralising antibodies to anthrax toxin
with Soligenix's second generation DNI subunit protein anthrax vaccine candidate, called VeloThrax
However, researchers at the Stanford University School of Medicine in the United States have discovered that susceptibility to anthrax toxin
is a heritable genetic trait.
Pharmacokinetic analysis suggested that doses as low as 1 mg/kg resulted in circulating levels of antibody after a month, with a similar potency for neutralizing anthrax toxin
in vitro as was seen with serum obtained from subjects who had been vaccinated with anthrax vaccine.
Using a submicroscopic packet called a liposome, scientists neutralized anthrax toxin
in rats (16.
Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin
Even the anthrax toxin
is being evaluated as a choice for tumor cell surface targeting in chemoresistant neoplasms (5).
Two victims showed weak signs of the main anthrax toxin
in tests at the top-secret Porton Down base in England but Greater Glasgow Health Board were quick to allay fears of an epidemic.
The Porton Down scientists said two of the victims' blood samples tested positive for main anthrax toxin
, Protective Antigen.