Training of Different Endoscopic Skills on Ex-Vivo Animal Model
For more information on the new animal model
, go to (http://www.
Three other Society-funded projects are also looking at animal models
of depression that encompass deficiencies in 5HT synaptic function display a uniform set of behavioral parallels: locomotor hyperactivity and increased open-arm time in the elevated plus maze, anhedonia in the chocolate milk consumption test, and cognitive impairment; all of these resolve with therapies that restore 5HT function to normal (Cairncross 1984; Cryan et al.
In part because of biologists' growing capability to genetically engineer mice, the number of these animal models
has exploded over the past decade.
Weiss, your lab is currently using an animal model
that is proving highly useful.
Yet even with an animal model
, researchers say it may take many years to find a promising drug that works in humans.
Innovative approaches to isolate, characterize, and identify totipotent and multipotent stem cells from nonhuman biomedical research animal models
, as well as to generate reagents and techniques to characterize and separate those stem cells from other cell types, is encouraged.
Specific scientific priorities that remain to be addressed include 1) obtaining further sequence data from the terminal regions of additional variola isolates, 2) continuing efforts to effectively detect variola virus infection and validate these procedures, 3) developing new drugs for smallpox treatment, 4) developing less reactogenic vaccines to protect against smallpox infection, and 5) validating an animal model
of human smallpox to allow assessment of candidate drugs and vaccines for both efficacy and regulatory purposes.
Scientists say the accomplishment will provide the first animal models
to test experimental treatments for human hemoglobin disorders such as sickle cell anemia.
Any non-mammalian or mammalian animal model
may be used, as long as it contributes to the common overall theme or objective of the program project.