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For the patients with unilateral renal artery stenosis with resistivity index > 0.8, we used fixed combinations: angiotensin-converting enzyme inhibitors and diuretic-Perindopril/Indapamide 2.5/0.625 mg; 5/1.25 mg; 10/2.5 mg or angiotensin II receptor antagonists
and diuretic-Telmisartan 40 mg; 80 mg and Indapamide 1.5 mg.
Nonpeptide angiotensin II receptor antagonists
: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxyliv acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.
These include ACE inhibitors, such as Altace (ramipril), and angiotensin II receptor antagonists
, such as Diovan (valsartan).
Whereas, the exclusion criteria included patients having a current diagnosis of type 1 or type 2 diabetes mellitus, patients on antihypertensive therapy or any drug that affects blood pressure, patients with a history of hepatic, cardiac, renal or blood diseases or other diseases which may interfere with the study, patients having hypersensitivity to angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists
, patients with a history of severe or resistant hypertension, patients with secondary hypertension of any etiology, pregnant or breast feeding women, and patients with serious disorders which may limit the ability to evaluate the efficacy of the trial drugs.
24 October 2011 - The European Medicines Agency (EMA) said in a press release on Thursday that its Committee for Medicinal Products for Human Use (CHMP) had reviewed the possible connection between the use of angiotensin II receptor antagonists
(ARBs) and the occurrence of new cancers and concluded that the evidence does not support any increased risk of cancer in patients using these medicines.