APP

(redirected from Amyloid precursor protein)
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Related to Amyloid precursor protein: amyloidosis, Tau protein

Application

1. A formal request. Generally, one must fill out an application form as part of the application process.

2. See: Application Program.

APP

Shorthand for appreciation.
References in periodicals archive ?
Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.
MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons.
DSCAM is expressed in the hippocampus of (A) wild-type (WT) and (B) amyloid precursor protein (APP) transgenic mice.
The role of ubiquitin-proteasome in the metabolism of amyloid precursor protein (APP): implications for novel therapeutic strategies for Alzheimer's disease.
Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.
Scherping et al., "Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice," Neurodegenerative Diseases, vol.
In murine model, it has been shown that the host protein Amyloid-a protein is composed of 40 to 43 amino acids which is generated from amyloid precursor protein (APP), by the proteolytic cleavage, which is a ubiquitous transmembrane protein involved various cellular processes such as neuronal protein trafficking along the axon, neurite outgrowth and synaptogenesis, transmembrane signal transduction, Ca2+ signaling and cell adhesion (20,21).
However, it will be interesting to see if amyloid-based therapies are useful in genetic cases (amyloid precursor protein and presenilin 1 or 2) of AD.
Furthermore, beta amyloid precursor protein cleavage enzyme 1 (BACE1), a member of aspartyl protease family, is known to play an important role in the cellular pathways leading to Alzheimer's disease [2].
The hallmark of the disease in the brain is the accumulation of soluble amyloid beta protein (A[beta]) which is produced by cleavage of the amyloid precursor protein [1].
A first step to accumulating beta amyloid is the production of amyloid precursor protein (APP).
Prochiantz, "Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro, " Journal of Cell Biology, vol.