Tests were started with the first step of the test strategy, the Ames test
, in five bacterial strains.
The second option does not require in vitro mammalian testing, but clearly does not prevent the use of existing or alternative methods to screen out genotoxins missed by the Ames test
What's more, Petrakis says, secretion from "8 percent or so of the women came up positive in the Ames test
," a bacterial assay to identify possible carcinogens.
An example of a service witnessing significant demand is its new microAmes test which saves pharmaceutical companies time and money by fully predicting the GLP regulatory Ames test
using milligram quantities.
That the predictive value of the Ames test
was overstated (Frickel 2004) only served to stimulate the development of short-term, in vitro tests for carcinogenicity.
Keywords: Antimutagenicity; Green tea; Polyphenols; Tobacco; Ames test
Using the Ames test
, the team assayed the smoke's mutagenicity, a rough gauge of carcinogenicity.
Midwest BioResearch, LLC (MBR), an outsourced drug disposition and toxicology contract services provider, today announces the introduction of a novel microAmes screen that fully predicts the GLP regulatory Ames test