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Kawamoto et al., "Adrenomedullin
: a novel hypotensive peptide isolated from human pheochromocytoma," Biochemical and Biophysical Research Communications, vol.
(ADM), a potent and long-lasting vasoactive peptide, was originally isolated from human pheochromocytoma in 1993 .
Distribution and characterization of immunoreactive adrenomedullin
in human tissue and plasma.
 showed that acute bout of static handgrip exercise increases adrenomedullin
(ADM) in healthy individuals and mild-heart failure patients.
Furthermore, EAT is also responsible for high quantity release of adrenomedullin
(OMIM 103275), a potent vasodilator peptide with 52 amino acid residues which is produced in a variety of peripheral organs, mainly in kidneys, lungs, adrenal glands, adipocytes, and cardiovascular system .
mediates the innate immune milieu of the placenta.
Abbreviations: ADM: adrenomedullin
; COC: cumulus--oocyte complex; Cx: connexin; eCG: equine chorionic gonadotropin; EGF: epidermal growth factor; ERK: extracellular signalregulated kinase; FSH: follicle-stimulating hormone; GAG: glycosaminoglycan; GVBD: germinal vesicle breakdown; HA: hyaluronan; has: hyaluronan synthase; hCG: human chorionic gonadotropin; MAF: meiosis-arresting factor; MAPK: mitogen-activated protein kinase; MPF: maturation-promoting factor; oGAG: ovarian glycosaminoglycan; PMSG: pregnant mare serum gonadotropin; VEGF: vascular endothelial growth factor.
injection of two peptides of the calcitonin family, CGRP and adrenomedullin
, increase c-Fos expression in the spinal cord of rats.
Epithelium Antibacterial, mitogenic, vasodilator, inducible peptide.
Increased oxidative stress is associated with elevated plasma levels of adrenomedullin
in hypertensive patients with type 2 diabetes.
Yildirim (2010).Investigation of some antioxidant enzymes activities depending on adrenomedullin
treatment and cold stres in rat liver tissue.