Renal transplants: can acute rejection
and acute tubular necrosis be differentiated with MR imaging?
Low tacrolimus concentrations and increased risk of early acute rejection
in adult renal transplantation.
The logarithmic transformed mRNA levels of perforin and TIM-3 were higher in leukocytes from patients with acute rejection
than in patients without rejection.
In our patient, positive C4d immunostaining was an isolated finding on a planned allograft biopsy performed on POD 711; no clinical signs of rejection were observed, histopathology was not consistent with acute rejection
, and the patient has not developed DSA.
The incidence of post-transfer predictors (medication nonadherence, acute rejection
, change in kidney function) and the outcome of graft loss were analyzed by post-transfer time (see Table 2).
is characterized by a perivascular mononuclear cell infiltrate with or without endothelialitis.
Chen et al., "Pre-transplant soluble CD30 level as a predictor of not only acute rejection
and graft loss but pneumonia in renal transplant recipients," Transplant Immunology, vol.
Of the 73 first episodes of CMV infection/disease, 56 (77%) occurred in high risk patients during preemptive therapy (1 D+/R-, 38 who received induction therapy, and 17 after treatment of acute rejection
) and 17 (23%) in low risk patients (no induction, no D+/R-, no acute rejection
) who had not received preemptive therapy.
The data were collected 1, 6, and 12 months after transplantation, and included presence of delayed graft function (DGF), acute rejection
episodes, total hospital stay, and the laboratory parameters.
Results: Multivariate analysis indicated that only partial liver graft (odds ratio [OR], 2.741; 95% confidence interval [CI], 1.236-6.077; P=0.013) was an independent risk factor for early-onset BC after LT, whereas acute rejection
(OR, 6.556; 95% CI, 2.380-18.056; P < 0.001), multiple bile ducts (OR, 4.227; 95% CI, 1.212-14.740; P = 0.024), and pre-LT serum albumin level (OR, 2.234; 95% CI, 1.178-4.238; P = 0.014) were the independent risk factors for late-onset BC after LT.
As described in a study involving seven transplant centers recently published in the American Journal of Transplantation, peripheral blood gene expression profiling was used to classify kidney graft recipients into three key categories of graft status (acute rejection
, acute dysfunction no rejection, an stable graft performance) with very high predictive accuracy.
Although development of immunosuppressive drugs and improvement of surgical techniques has been improved the outcome of kidney transplantation, acute rejection
is a common phenomenon in transplantation .