Caption: Figure 12: Bland-Altman plots of HRV indices calculated for ECG channel 1 and ECG channel 3 with limits of agreement (blue dashed lines), bias (black lines), and acceptance limits
(red dotted lines).
The recovery of drug from plasma was found between 77.49 - 86.82% with mean value of 81.70% +- 4.08 which is within the acceptance limit
of [greater than or equal to] 70% (Table-5).
Any deviations over certain limits must be reviewed, and if the deviations are not within the acceptance limits
of the standard, corrective action must be taken.
Analytes or tests for which proficiency testing participation is required per CLIA Subpart I Although PT programs may use either of the two approaches mentioned above to set the target value for quantitative analytes, they most frequently peer group results based upon their use of a common method platform and/or reagents to establish target values and determine whether each peer group can be graded based on the requirement for 80% of results to fall within the acceptance limits
. Therefore, for a particular challenge, there may be a dozen or more peer groups, each with a separate target for acceptable performance.
Automated HCT is often lower than spun HCT in this case; some labs use only automated value for HCT and allow about 20% acceptance limit
between the two methods.
Last but not least, the main objective of the Bland-Altman approach, namely, comparison of the experimentally observed deviations with a preset clinical acceptance limit
, is seldom followed despite recommendations for doing so that were given earlier in this journal (11).
 used ratio plots in their validation protocol of analytical hemostasis systems, where they used a preset, but arbitrarily chosen, acceptance limit
of inaccuracy of 15%.
, within which the 2 analyzers were considered analytically identical (thereafter referred as analytical agreement), were defined as: 0 [+ or -] 1.96 * CV, where CV was the combined CV of both techniques [CV = V(C[V.sub.1.sup.2] + C[V.sub.2.sup.2])].