APP

(redirected from Abeta)
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Application

1. A formal request. Generally, one must fill out an application form as part of the application process.

2. See: Application Program.

APP

Shorthand for appreciation.
References in periodicals archive ?
Increased amount of APP might lead to heightened levels of Abeta generation, whereas lower levels of APP could also bear certain risks, such as impaired muscular function and spatial working memory (Senechal et al.
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.
In addition, some of the fragments of APP could be neuroprotective, making it difficult to judge whether drugs are being effective due to their effect on Abeta peptides, which are known to be involved in human AD, or whether it is due to other effects that would not be seen in human disease.
The mice showed early accumulation of Abeta peptides, and importantly, were found to undergo cognitive dysfunction similar to the progression of AD seen in human patients.
Neither bapineuzumab, which targets soluble and aggregated amyloid-beta (Abeta), nor solanezumab, which targets soluble Abeta, achieved the primary endpoints in their overall cohorts, investigators wrote.
Solanezum-ab increased Abeta in plasma and CSF, a sign that the protein had stopped clumping in the brain.
8220;One of the major pathological hallmarks of Alzheimer's disease is the progressive accumulation of Abeta proteins in the brain, and this accumulation disrupts nerve cell function,” Ziburkus said.
The Abeta sample was present in two forms, fibrillar and oligomeric.
The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease.