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Related to ATP7B: ceruloplasmin

When Issued

Referring to a conditional offer for a new security, subject to the security actually being issued. Before a new issue, underwriters canvass potential investors, who may or may not book an order to buy a portion the new issue. Orders made are said to be effective "when issued" because they may not be completed, especially if the offering is cancelled. Less formally, orders when issued are referred to as orders "with ice" or orders "when distributed."


Used on the consolidated tape to indicate that a stock is trading on a when-distributed basis: GY.WD 52.


Used in stock and bond transaction tables in newspapers to indicate that a security is trading on a when-distributed basis: ColgP wd.
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References in periodicals archive ?
8) suggest the analysis of 4 informative SNP markers within ATP7B, which they identified in a cohort of 1871 analyzed patients.
Mutation analysis of the ATP7B gene and genotype/phenotype correlation in 227 patients with Wilson disease.
Mutation analysis of Wilson disease in the Spanish population: identification of a prevalent substitution and eight novel mutations in the ATP7B gene.
High frequency of two mutations in codon 778 in exon 8 of the ATP7B gene in Taiwanese families with Wilson disease.
ATP7B protein has dual roles: copper transport, which is reflected by serum ceruloplasmin concentrations, and cellular trafficking.
We found disease-causing mutations in all WD patients except for 2 patients in whom only 1 mutation was found after sequencing all the coding exons of ATP7B and about 1 kb of each 5' and 3' untranslated region including the promoter region.
On direct DNA sequencing of all exons of the ATP7B gene, we found that patient P5 was heterozygous for a known disease-causing mutation, c.
In WD, an autosomal recessive disorder, mutations in the ATP7B gene lead to accumulation of copper in the liver and the brain (2).
Wilson's disease results from a mutated version of the gene ATP7B that when inherited from both parents causes liver and neurological damage and eventual death.
Similar effects were observed with the ATP7B gene and the LightCycler Control Kit (Roche), and the effect was even stronger on a LightCycler 1.
About Wilson Disease Wilsons Disease is a rare autosomal recessive disorder caused by mutations in the ATP7B gene resulting in deficient production of the copper-transporter ATPase-2.