To discriminate the ADRB2
Gly16Arg and Glu27Gln, ADRB3 Trp64Arg as well as ADRA2A G1780A alleles, TaqMan[R] Pre-Designed SNP Genotyping Assays were used (assay IDs: C_2084764_20, C_2084765_20, C_2215549_20 and C_996424_20, respectively), including appropriate primers and fluorescently labelled (FAM and VIC) MGB[TM] probes to detect the alleles.
For association between asthma and gene polymorphism the search terms used were: "Asthma* AND Polymorph* OR mutation OR variant AND beta2* OR b2 OR ADRb2
OR Adrenergic receptor b2".
genomic DNA and amino acid sequences of various species (horse, human, chimpanzee, mouse, rat, cow, pig, chicken, dog, and cat) were retrieved from the Ensemble database (http://www.ensembl.org/) and aligned with BioEdit software using the ClustalW method.
(35) Arg16 to Gly polymorphisms in the ADRB2
gene, the product of which effects smooth muscle contraction, have been observed in blood samples from CRS patients with polyps compared with controls.
is the gene for the beta-2 adrenergic receptor (Warrier and Khurana Hershey 2008).
Polymorphic variants of the beta2-adrenergic receptor (ADRB2
) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population.
In an earlier study, the researchers identified other common genetic variants associated with lung cancer risk in NNK disposition pathways, such as CYP2A13, the most active P450 for the phase metabolic activation of NNK and the receptor (ADRB2
) in its non-genotoxic pathway.
Tambem outros, relacionados com o metabolismo, como e o caso da adenosina desaminase (ADA), da fosfatase acida (ACP1), de determinados neuropeptidos hipotalamicos e seus receptores (MCR3,4 e 5, POMC, NPY) e dos receptores adrenergicos (ADRB2
Recent studies have revealed that beta-2 adrenergic receptor (ADRB2
) polymorphism may mediate the bronchodilation response to LABA, thereby influencing the clinical effectiveness of combination treatment .
The gene expression of four adrenoceptors, alpha 1(ADRA1A), alpha 2 (ADRA2A), beta 1 (ADRB1), and beta 2 (ADRB2
), as well as of three muscarinic receptors, M2 (CHRM2), M3 (CHRM3), and M4 (CHRM4), was detected with high expression of beta 2 (ADRB2
) and M3 (CHRM3) (Figure 3).
(2012) found high N[O.sub.2] exposures associated with more severe asthma in children with high beta-2-adrenergic receptor (ADRB2
) gene methylation.
R16G, a polymorphism of the [beta]2-adrenergic receptor gene, may be strongly associated with airway hyperresponsiveness following activation by [beta]2-adrenoceptor agonists (11).