Determination of the designer drugs 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxy ethylamphatamine, and 3,4-methylenedioxyamphetamine
with/HPLC and fluorescence detection in whole blood, serum, vitreous human, and urine.
The designer drugs 3,4-methylenedioxyamphetamine
(MDA)  3,4-methylenedioxymethamphetamine (MDMA; ecstasy; adam), and 3,4-methylenedioxyethylamphetamine (MDEA; eve) are recreational drugs that are particularly popular among young people in the so-called "rave scene".
The analytical procedure was tested for interference with the following phenylpropylamine derivatives and common sympathomimetic amines: amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine
, 3,4-methylenedioxymethamphetamine, ephedrine, pseudoephedrine, N-methylephedrine, amphetaminil, etilefrin, fencamfamine, fenethylline, fenfluramine, fenproporex, mefenorex, norfenefrine, phenylephrine, methylphenidate, diethylpropion, propylhexedrine, and prolintane.
Simultaneous chiral separation of 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine
, 3,4-methylenedioxyethylamphetamine, ephedrine, amphetamine and methamphetamine by capillary electrophoresis in uncoated and coated capillaries with native R-cyclodextrin as the chiral selector: preliminary application to the analysis of urine and hair.
The aims of this study were as follows: (a) to investigate the presence and the concentration of MDMA and its main metabolites, 3,4-methylenedioxyamphetamine
(MDA) and 4-hydroxy-3-methoxymethamphetamine (HMMA), in saliva; (b) to assess the eventual correlation between salivary and plasma MDMA concentrations; and (c) to determine the effect of salivary pH on the MDMA saliva-to-plasma (S/P) ratio.
The designer drugs 3,4-methylenedioxymethamphetamine (MDMA,;  ecstasy), 3,4-methylenedioxyethylamphetamine (MDEA; eve), and 3,4-methylenedioxyamphetamine
(MDA), the latter being a designer drug but also an important metabolite of both MDMA and MDEA, are all methylenedioxyamphetamine derivatives (Fig.
(MDA), itself a popular drug of abuse in the 1960s [known as the "Love Drug" in the US (2)], is the N-demethylated metabolite of MDMA (3).