Perhaps the single most important finding is that people who reach an undetectable viral load
with antiretroviral therapy (called medical controllers in this study) get admitted to the hospital significantly less often than elite controllers (people who maintain an undetectable viral load
without the help of drugs).
The researchers speculate that the higher rate of untreated co-infections in Africa could be to blame, and cite a 2002 paper from Uganda that shows that a herpes attack can raise HIV viral load
by 50%, active tuberculosis by 150%, and acute malaria by 370% (a nearly fivefold increase).
During the study, lead researcher John Crump and colleagues from Duke University examined Tanzanian infants born to HIV-infected parents and people with known HIV infections who needed monitoring of their viral loads
So, for example, when a woman on HAART comes to me and says she wants to have a baby, there is no way to assure her, even if she has a below detectable plasma viral load
, that it's safe to have unprotected sex.
While clinical malaria leads to at least short-term HIV viral load
increases in adults (1,2), the effect of subclinical malaria is unclear, and even less is known about coinfection in children.
There were too few instances of virus with the K65R mutation in patients receiving the 200 mg dose to draw firm conclusions; however, the viral load
reduction in patients with the K65R mutation treated with lower doses of Reverset suggests that the compound is also active against this mutation.
Multiple groups report continued viral replication even in patients with "undetectable" viral loads
, suggesting that viral reservoirs persist even in the presence of suppressive therapy.
Patients who scored high in depression tended to show increases in viral load
Different viral load
cutoffs were analyzed using ROC curves.
I would weigh the CD4+ [T-cell] count probably a little bit more than the viral load
, but you have to look at the whole clinical picture.
is a quantitative measurement of the number of HIV particles contained in an HIV-infected patient sample and is used as a tool to monitor the effectiveness of drug treatment regimes.
Neil Graham of Johns Hopkins University in Baltimore, one of several researchers who presented viral load
studies last month during the International Conference on AIDS in Vancouver, British Columbia.