People with positive tuberculin skin tests
and abnormal chest x-rays compatible with inactive TB (lesions caused by prior disease);
The International Unit Against Tuberculosis (IUAT) trial, conducted in Eastern Europe, randomized approximately 28,000 individuals with positive tuberculin skin tests
(TST) and fibronodular changes on chest X-ray (12).
Both our patients had reactive tuberculin skin tests
Commercial interferon gamma release assays compared to the tuberculin skin test
for diagnosis of latent Mycobacterium tuberculosis infection in childhood contacts in the Gambia.
QFT(TM) is the first major advancement in TB diagnosis since the introduction of the Mantoux or tuberculin skin test
(TST) over 100 years ago.
QIAGEN's QuantiFERON-TBGold is a more accurate, easier-to-handle alternative to the tuberculin skin test
- a modern approach for latent TB infection screening in an integrated TB control program.
These include, for example, novel approaches to informed consent, (9) tools to measure the tuberculin skin test
, (10) approaches to diagnosing TB disease in children for late-phase vaccine trials, (11) and detailed studies of the vaccination-induced immune response.
3) In such countries, standard TB-screening tests, recommended by the World Health Organization (WHO), continue to be sputum microscopy and the tuberculin skin test
(TST)--both largely unchanged for 100 years and incapable of identifying drug-resistant strains.
The tuberculin skin test
(TST), involving the intra-dermal inoculation of a known amount of tuberculin protein, followed by the recording and interpretation of the subsequent induration, measures some aspects of the host's cell-mediated immune response to TB.
In a landmark study electronically published today in the American Journal of Respiratory and Critical Care Medicine, a blood test for detecting TB infection, QuantiFERON(R)-TB Gold (QFT(TM)), has been shown to be six times more accurate than the conventional tuberculin skin test
(TST) at predicting which tuberculosis (TB)-exposed individuals will go on to develop TB disease.
This class of tests, called in vitro T-cell-based interferon-[gamma] release assays (IGRAs), is the first replacement for the flawed tuberculin skin test
, which has been in use in one form or another for a century.
Purified protein derivative (PPD) of tuberculin skin test
, CSF tuberculosis DNA polymerase chain reaction (PCR), herpes simplex virus DNA PCR, and CSF cultures were all negative.