Blood flow should be balanced between the pulmonary and systemic circulations
While the mean duration of follow-up in patients with the right ventricle supporting the systemic circulation
In some cases when the drug needs to reach the systemic circulation
quicker, or when the drug has a shorter half life, often seen during emergencies, the drug will be administered by injection, for example, intravenously (i.
For these reasons the vascular pressures and vascular resistance throughout the pulmonary circulation are extremely low compared to the systemic circulation
The gel bypasses gastrointestional absorption, hepatic "first-pass" metabolism, and systemic circulation
, which are associated with oral therapies.
The recombinant hyaluronidase, injected before the IG, facilitates the dispersion and absorption of the IG product to improve bioavailability and increase the amount of infused immune globulin reaching the systemic circulation
compared to when IG is administered subcutaneously alone.
In animal studies, we were unable to detect any decoy drug in systemic circulation
ViaDor or the "golden path" expresses the capabilities of TransPharma's system to introduce drugs to the systemic circulation
without pain or discomfort and also alludes to the transdermal "doors" - the microscopic channels the system creates in the upper layer of the skin that enable an efficient delivery of a wide array of drug-molecules.
Vice President of Research at KemPharm, commented, "The results of this study confirm two key benefits of KP201 and of our novel prodrug approach to abuse deterrence: 1) single and multiple doses of KP201 tablets release hydrocodone effectively only upon oral administration, and 2) the prodrug itself is metabolized completely and does not reach the systemic circulation
, even at the maximum daily dose.
For whole-limb perfusion, the limb is tied off from the systemic circulation
Our cryopelletization technology can improve the quality and lower the cost of countless drugs worldwide that require bulk lyophilization in their manufacture, and our innovative, non-invasive drug delivery system can transport a potentially endless variety of macromolecules into the systemic circulation
via the pulmonary route.
Various parameters were monitored for systemic side effects: ECG, blood biochemistry, blood count, urinalysis, assessments of the incisions by physician and subjects and measurement of RXI-109 into the systemic circulation
after intradermal injection.