The 20-mg/kg BPA dose was selected based on pharmacokinetic data from a preliminary experiment in order to obtain plasma concentrations of unconjugated BPA of the same order as those observed after sublingual administration
of BPA at the TDI dose level.
Adverse events commonly observed with the sublingual administration
of SUBOXONE Sublingual Film are oral hypoesthesia, glossodynia, oral mucosal erythema, headache, nausea, vomiting, hyperhidrosis, constipation, signs and symptoms of withdrawal, insomnia, pain, and peripheral edema.
Activity and tolerability of buprenorphine after parenteral and sublingual administration
Data from the study showed that the combination therapy was generally well tolerated and sublingual administration
of ALKS 33 effectively blocked the agonist effects of buprenorphine.
But because of ketamine's hallucinogenic effect, when a mild sedation with short-last effect is needed, sublingual administration
of midazolam in 2.
A pioneer and a leader in immunotherapy treatments by sublingual administration
, Stallergenes dedicates more than 20% (gross) of its sales to its Research and Development activities, which are primarily directed at developing a new therapeutic range enabling the provision of immunotherapy treatments by sublingual tablets.
Rapinyl is based on Orexo's unique proprietary technology for sublingual administration
, where a tablet is placed under the tongue and rapidly disintegrates into ordered mucoadhesive units of the active substance.