Of the individual morphologic features of NASH, pericellular fibrosis and portal fibrosis were the only ones associated with splenomegaly
, even when using higher thresholds for the definition of splenomegaly
(P < .
can become severe enough to threaten rupture, necessitating splenectomy.
Myelofibrosis with myeloid metaplasia: Pathophysiologic implications of the correlation between bone marrowchanges and progression of splenomegaly
There was no significant difference between homozygous and heterozygous with any of the factors such as disease subtype, age, sex, splenomegaly
, WBC count and haemoglobin level and platelet count.
, hepatomegaly, increased renal cortical echogenicity, lymphadenopathy, thickened bowel walls and fluid-filled bowels correlated with CD4+ counts.
The common features include generalised lymph node enlargement (Figure 1), which is present in very nearly all cases, and splenomegaly
(Figure 2), which was present in all patients who had a spleen in situ, whilst hepatomegaly was a less universal finding present in 75-85% of patients [11,13].
The ruptured spleen weighed 727 g, and splenomegaly
was associated with marked sinus histiocytosis spreading apart the lymphoid component.
The disease may first be noticed in childhood or in early adult life, when microcytic hypochromic anemia and splenomegaly
Clinically he presented with undulating high fevers, tachycardia and was markedly pale, with generalised shotty cervical lymphadenopathy and mild splenomegaly
Abdominal pain is rare in the presence of splenomegaly
, so its onset should alert the clinician to the possibility of splenic rupture, as it did in our case.
Approximately half of all adult patients with ALL have lymphadenopathy, hepatomegaly or splenomegaly
Current guidelines for HS diagnosis include family history, splenomegaly
, abnormal CBC indices [spherocytes identification; increase in MCHC (mean corpuscular hemoglobin concentration)], reticulocytes, and RDW (red cell distribution width); and decrease in Hb (hemoglobin) and MCV (mean cell volume), a negative direct antiglobulin test, increased bilirubin, and reticulocytosis.