Heinz bodies are removed by the reticuloendothelial
system, leaving erythrocytes with a missing section of cytoplasm seen as bite cells in routine blood smear (6).
It has been suggested that Nramp1 may also be a divalent cation transporter; its role in reticuloendothelial
cells remains unexplored (40,44).
During the scavenging process, both G-actin-gelsolin and G-actin-Gc-globulin complexes are formed and subsequently cleared by the reticuloendothelial
system much more efficiently than the free proteins, which have half-lives of ~1 day (Gc-globulin) and 2 days (gelsolin), respectively.
As the name implies, tissue-specific contrast agents are targeted at a specific tissue type (eg, reticuloendothelial
cell-specific or hepatocyte-specific) or organ (eg, blood-pool agents for the vascular system or enteral agents for bowel).
In affected patients, platelets are sensitized with antiplatelet antibodies and then destroyed by the reticuloendothelial
Infections in these patients localize to the viscera rather than the skin, and parasites are found throughout the reticuloendothelial
White Blood Cell and Reticuloendothelial
System Disorders: cervical lymphadenopathy, eosinophilia
Autosomal dominant reticuloendothelial
iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).
Cirrhosis of the liver has been shown to cause severe alterations of the immune system, such as neutrophil dysfunction, impaired function of the reticuloendothelial
system, and complement deficiency, predisposing to invasive infections.
Idiopathic thrombocytopenic purpura is known to be due to platelet sensitization, with autoantibodies leading to platelet destruction in the reticuloendothelial
system; peripheral smears may show variable macrothrombocytopenia and autoantibodies to specific surface glycoproteins can be detected by flow cytometry or immunoassay, (95) although diagnosis is largely from clinical findings.
VIRULIZIN, a biological response modifier (BRM) of bovine reticuloendothelial
origin, is extracted using Imutec's proprietary technology.
r] 37 000 and 77 000, respectively), it is unlikely that the kidney will represent the main clearance mechanism, and it is probable that clearance occurs via the reticuloendothelial