studies have established that drug-eluting stents are much more effective at preventing restenosis than their bare metal predecessors, which have no drug coating.
In a second presentation, data were presented for patients randomized
to the twice-daily stavudine arm of Study 903 who were switched and received two additional years of open-label therapy with once-daily Viread, lamivudine and efavirenz in Study 903E.
Dimebon(TM), with a 20-year record of human use, has generated positive results in a randomized
, double-blinded, placebo-controlled Phase 2 study in Alzheimer's disease patients, as well as in animal studies of both Alzheimer's disease and Huntington's disease.
As a consequence, relatively few foundations have funded randomized
trials that generate evidence about whether the programs that they support actually work, Nonetheless, a few foundations seem admirable in subsidizing field tests that 1) a national, state, or local government is unable or unwilling to mount; and 2) build on government investments in randomized
field trials to generate new knowledge.
Emerging data from several randomized
trials suggest that chemotherapy administered during radiation might improve local control rates (and in some instances even survival rates) to a greater degree than does radiation alone (15-17) The results of a large, well-done meta-analysis by Pignon et al, who looked at the effects of chemotherapy added to locoregional treatment, suggested that a significant survival benefit (8%) was associated with concomitant chemoradiation schedules.
In a prospective, randomized
trial of catheters in place for an average of 15 to 16 days, use of a hub with the antiseptic chamber reduced the incidence of infection (RR 0.
6]/L CD4 cell counts: A randomized
One issue that there appears to be universal agreement on is the importance of participation in clinical trials, specifically randomized
phase III trials.
The trial, CPCRA 002, was a prospective, randomized
comparison of VIDEX versus ddC conducted by the Community Programs for Clinical Research on AIDS (CPCRA) of the National Institute of Allergy and Infectious Disease (NIAID).
Worse yet, they concluded that existing evidence that fat promotes breast cancer is too weak to justify any large-scale randomized
trial on fat and breast cancer.
The Prospective Randomized
FDA IDE Study Assesses the Safety and Efficacy of CORTOSS Bone Augmentation Material for the Treatment of Osteoporotic Vertebral Compression Fractures as Compared to Commercially Available Polymethylmethacrylate (PMMA) Bone Cement
The overall cure rates for the various agents were substantially lower in the randomized
controlled trials than in open studies.