When the cells or tissues had oxygen deficits, however, ATP levels in the liver were reduced much more dramatically in the alcohol-consuming than in the control animals (Spach et al.
Other evidence indicates that alcohol also interferes with glycolysis, resulting in reduced ATP synthesis, particularly in the presence of oxygen deficits.
The observations discussed in these sections suggest that the perivenous hepatocytes of alcohol consumers experience more severe oxygen deficits, limiting the cells' ability to generate ATP in the mitochondrial respiratory chain.
The increased demand for oxygen, in turn, can lead to oxygen deficits at least in certain regions of the liver lobules (i.
Because ATP synthesis, particularly in mitochondria, requires oxygen, oxygen deficits in the liver can lead to reduced ATP production, with potentially detrimental effects to cells.
All forms of chronic cellular injury involve functional oxygen deficit (dysox).
Why did the larger threat of oxygen deficit escape the notice of biologists, physicians, and the public?
Recent reports of anoxic waters are disturbing both for the degrees of oxygen deficit and for the frequency with which such deficits are encountered, especially the finding of fatal anoxia in the bodies of water in which anoxia was not previously present.
For optimal sustenance of oxygen-utilizing life forms, an aquatic ecosystem must not develop oxygen deficits that allow the dissolved oxygen levels to fall below 80%.