Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase
with influenza virus neuraminidase
Caption: In this cartoon, neuraminidase
is depicted as a mouth which "bites" the bond between hemagglutinin (blue suction cup) and sialic acid (green rod).
When total sialic acid level was found to be very high, a diagnosis of sialidosis was made observing that [beta]-galactosidase enzyme activity was normal, but there was no activation of neuraminidase
enzyme in fibroblast culture.
Positive test results can prompt early, appropriate initiation of neuraminidase
Laninamivir is a neuraminidase
inhibitor administered only by inhalation.
Influenza A virus strains are categorized according to two proteins found on the surface of the virus: hemagglutinin (H) and neuraminidase
Researchers searched databases for studies of the use of neuraminidase
inhibitors, like Tamiflu and Relenza, for the treatment of seasonal influenza.
Initial testing of the 2009 pandemic influenza A (H1N1) virus found it susceptible to neuraminidase
inhibitors (oseltamivir and zanamivir) and resistant to adamantanes (amantadine and rimantadine) (1).
HN also acts as an enzyme (NA, neuraminidase
or sialidase) that removes sialic acid (neuraminic acid) moieties from viral progeny to prevent self-aggregation, favoring the release of virions from the cell.
inhibitors are an important adjunct to influenza vaccination.
4,5) It is a transition-state analogue of sialic acid that potently inhibits the neuraminidase
enzymes of both influenza A and B viruses.
Tamiflu is a neuraminidase
inhibitor but experts argued that the Government should also be stocking another type of drug, known as ion channel inhibitors.