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Kim, et al, found the PHH3 counting method in the detection of mitotic figures was more sensitive compared with the traditional H&E-stained mitotic figure counts; and if the mitotic thresholds suggested by the WHO were applied to the PHH3 MI results in 28 cases, there would be a change in grade.
Cytological atypia or mitotic figures were not identified.
Numerous mitotic figures and single apoptotic cells were present (Fig 3a).
Occasional apoptotic and mitotic figures were also present.
Mitotic figures are usually easily identified, while necrosis tends to be limited to thermal or electrical injury cases.
Vertical growth phase has been defined as "tumorigenic" growth when the dermal nests are larger than any nest in the junctional component of the lesion or when mitotic figures can be identified within the dermal melanocytes.
The tumour is composed of an admixture of spindled and pleomorphic cells with numerous mitotic figures (arrows) (A) and these tumour cells show immunoreactivity to vimentin (B) and CD68 (C).
Histologically, the mass was composed of interlacing bundles of pleomorphic spindle cells with numerous and bizarre mitotic figures.
suggested that the presence of three mitotic figures per 10 HPF is sufficient to designate sarcomas.
A prototypic histologic pattern of RN was described as consisting of a junctional melanocytic component with varying degrees of pigmentation overlying fibrous scar tissue and deep, residual, monomorphous nevus cells lacking mitotic figures (2); this pattern would later be termed trizonal.
Mitotic figures, including atypical forms, are usually easily identified (figure 3, A).