Heart-related problems have been reported with methylphenidate
hydrochloride and other stimulant medications:
But that drug also has been associated with priapism in children, teens, and adults, the report said--and it appears to be more common than among patients taking methylphenidate
The children were not randomly assigned to the treatment or nontreatment group: all those in the methylphenidate
group had responded to the drug in an initial three-week study.
In a phase III study, investigators randomly placed 270 participants in one of three treatment groups: a DAYTRANA patch and a placebo capsule, a placebo patch and an oral extended-release methylphenidate
capsule or a placebo patch and placebo capsule.
is a dopamine agonist and is readily absorbed orally, with a half-life of one to two hours (SAMF, 2003:449).
Finally, the fourth grader ended up on a long-acting form of methylphenidate
, Concerta, and the antidepressant Zoloft.
KP415 is Designed as an Abuse-Deterrent, Controlled Release Prodrug of Methylphenidate
for the Treatment of ADHD
Previous research has shown that oral methylphenidate
improved brain function in cocaine users performing specific cognitive tasks such as ignoring emotionally distracting words and resolving a cognitive conflict.
No published randomized controlled trials have examined methylphenidate
for treatment of such episodes in palliative care settings.
HONOLULU--High-dose OROS methylphenidate
was associated with small but statistically significant increases in systolic blood pressure and heart rate in a 6-month, open-label study in adolescents.
Children with attention-deficit hyperactivity disorder (ADHD) often calm down and behave better when taking the stimulant medication methylphenidate
Food and Drug Administration (FDA) for DAYTRANA (methylphenidate
transdermal system), an investigational transdermal patch formulation for methylphenidate
designed for once-daily use to treat attention deficit hyperactivity disorder (ADHD) in children aged 6 to 12 years.