Nephrogenic systemic fibrosis (NSF) may develop in patients with renal failure on gadolinium
administration and may even be life-threatening.
In all cases, FLAIR T2 sequences without and with gadolinium
and FLAIR T1 sequence with gadolinium
We examined the in vitro effect of three different gadolinium
formulations on calcium measurements obtained by two OCP-based calcium methods as well as their effect on an arsenazo-based method.
The permanent magnets and the gadolinium
don't require any energy inputs to make them work," Gschneidner explains, "so the only energy it takes is the electricity for the motors to spin the wheel and drive the water pumps.
As reported in the FDA-approved prescribing information, unlike other available gadolinium
contrast agents, MultiHance demonstrates weak and transient interactions with serum proteins, which result in a proton magnetic relaxivity that is approximately twice that of other gadolinium
contrast agents available for sale in the U.
The different structures of the ligands (shown in Figure 5) bound to the gadolinium
atom impart different imaging properties and stabilities.
chelate eventually detaches from the artery walls and is cleared by the kidneys.
Other brands of gadolinium
contrast also have been associated with NSF, including Magnevist, manufactured by Schering, and OptiMARK, manufactured by Mallinckrodt.
On MRI of the brain with gadolinium
contrast, the classic sign of intracranial hypotension due to a CSF leak is contiguous, pachymeningeal enhancement, Dr.
The lesions these scans reveal continue to show up as high-water bright spots after the gadolinium
enhancements have gone away.
ProHance is the only macrocyclic gadolinium
contrast agent available in the U.
is toxic, so it is chelated with another compound that reduces its toxicity by altering its pharmacokinetics.