For trisomies 21 and 18, the false-positive rates
returned by cell-free DNA testing were significantly lower than those returned by standard screening: 6 patients vs.
Whereas the review rates of the Unicel DxH 800 were relatively consistent, the XE 2100 presented a wide range of review rates, false-negative rates, and false-positive rates
according to the changes in cutoff levels of immature granulocytes and atypical lymphocytes.
by Preparation Type (N = 494) (a) Preparation Type Smears Papanicolaou Modified Giemsa Cytocentrifuged (N = 323) (N = 139) Specimen (N = 32) False-positive rate
, % 15.
Perhaps the most striking aspect of the second-tier test relates not only to its ability to reduce false-positive rates
derived from screening for the primary metabolite of a disorder but also to its capacity to expand the number of disorders by using the same screen for the same metabolite as a secondary metabolite for other diseases.
However, Carriquiry says that the 27 percent false-positive rate
is not informative.
Effectively, for PPV to support an expectation of a positive being more likely correct than not (PPV > 50%), the false-positive rate
, [alpha], must be less than double the likelihood of the hazard, P[H], a specification for a monitoring method that is challenging to provide for very low-frequency hazards.
Using the conventional 1:270 second-trimester cutoff for anticipated cases of aneuploidy, six of the seven cases screened positive, however, the price was an additional false-positive rate
Berlin would like them to also provide typical false-negative and false-positive rates
, the costliness and potential dangers of follow-up testing, and how frequently people need to be scanned to catch diseases as they develop.
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Contingent screening had a detection rate of 93%, with a false-positive rate
of 4% in a relative comparison of the three methods for detection of trisomy 21 in the FASTER population.
In one study conducted during the second trimester of pregnancy, ITA alone detected 78% of the Down syndrome cases at a 5% false-positive rate