The relationship of hyponatremia with frequency and severity of hepatic encephalopathy
was statistically significant.
Mithra now plans to develop E4 to treat Hypoxic Ischemic Encephalopathy
(HIE), which is a subset of NE and accounts for 50-80% of cases, affecting pre-term and newborn babies.
Minimal hepatic encephalopathy
(MHE) is the first phase in the clinical spectrum of HE, occurring in up to 30%-84% of patients with cirrhosis (1,2).
(HE) is a common and major complication of cirrhosis that impacts quality of life, increases the risk of accidents, and is associated with significant morbidity and mortality.
Studies of developing nations demonstrated that 18% of survivors with mild to moderate birth asphyxia had newborn encephalopathy
and long lasting severe neurological impairment.
Posterior reversible encephalopathy
syndrome (PRES) is usually a reversible condition characterized by a clinical picture of disturbance in mental state, headache, seizure, visual disturbances, and brain edema, which is more prominent in the parietal and occipital regions on brain imaging.
in chronic liver disease: 2014 practice guideline by the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases.
Until recently there were no proven treatments for newborns with encephalopathy
Various conditions that are considered in the differential diagnosis include acute cerebral ischemia, infarcts involving top of basilar syndrome, cerebral venous thrombosis, transient cerebral hyperemia, Creutzfeldt-Jakob disease, gliomatosis cerebri, infectious meningitis, encephalitis, post-infectious encephalomyelitis, vasculitis, epinephrine-induced toxic or metabolic encephalopathy
, and demyelinating disorders .
Additionally, the report provides an overview of key players involved in therapeutic development for Encephalopathy
and features dormant and discontinued projects.
Conclusion: Minimal Hepatic Encephalopathy
(MHE) could be detected in illiterate patients using NCT-A and BDT Tests.
Patients and Methods: All patients with cirrhosis of liver of more than 18 years of age, manifesting signs of hepatic encephalopathy
(HE) were included in the study.