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Half-Life
(redirected from effective half-life)

   Also found in: Dictionary/thesaurus, Medical, Encyclopedia, Wikipedia 0.01 sec.
Half-life

Half Life
In a pool of mortgages underlying a mortgage-backed security, the length of time it takes for half the aggregate principal to be repaid. A half life is normally about 12 years, but this may vary depending on how often homeowners refinance their mortgages (which pays off all principal at once). Half lives are calculated for mortgage-backed securities issued or guaranteed by Freddie Mac, Fannie Mae, and Ginnie Mae.

Weighted Average Life
The amount of time for the principal on a loan or a mortgage to be paid off. The length of the weighted average life depends on the amount of principal paydowns and how often they are made. Once the WAL is calculated, one can determine how long it will take to pay off half of the remaining principal.

half-life
The length of time before half the principal on a debt is expected to be repaid through amortization or sinking fund payments. For example, a 25-year bond issue may require the issuer to retire 5% of the beginning principal commencing 5 years after the issue date. Thus, the bond issue has a half-life of 5 years plus the number of years required to retire half the issue, or 15 years. Mortgage-backed securities often have a relatively short half-life because many homeowners pay off or refinance their mortgages early. Also called average life.


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For example, low doses of vitamin C are retained in the body and have an effective half-life of somewhere between eight and forty days.
In the liver, chemicals can be secreted into the bile and transported into the gut, where they are reabsorbed into the portal blood, thereby increasing the effective half-life for systemic clearance.
These extend to efficacy and safety, but also to important issues in drug development such as stabilization and the extension of effective half-life without affecting bioactivity," said Mr.
 
 
 
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