Concerns about HIVNET 012 have had "a chilling effect on the use of this drug
," says pediatrician Mark W.
Interestingly, Hoffman-LaRoche is now moving back to the original Invirase formulation of saquinavir (with a new 500-mg tablet) because it is better tolerated than the Fortovase version when the drug
is combined with ritonavir.
An alternate system would automatically switch a drug
once it's become an accepted part of the health care system.
Worst of all, when you take a drug
that isn't prescribed to you in a way you're not supposed to--by increasing dosages, mixing medications with alcohol or other drugs
, or snorting them or injecting them into your bloodstream--you can overdose and put your life at risk.
The draft guidance outlines the risk assessment procedure for new active pharmaceutical substances, their metabolites, and possibly excipients (the inert substances in which a drug
is delivered) if they are deemed similar to chemicals with known adverse environmental effects.
Sanofi-aventis and UCB Launch Prescription Allergy Drug
According to the 2005 Express Scripts Drug
Trend Report, specialty pharmacy increased 77% in 2005 from 2004, measured by clients' prescription volume basis.
Some changes in the brain and in functioning may be reversible when drug
use stops, but other changes appear to be either permanent or very long-lasting, leading to persistent deficits in memory and motor coordination (National Institute on Drug
Abuse, 2001; Tapert & Schweinsburg, 2005).
A March survey conducted by the Society for Human Resource Management found that 84 percent of the 454 employers contacted said they conduct pre-employment drug
testing; 39 percent do random drug
tuberculosis strains isolated, underwent antimicrobial drug
susceptibility testing in the system.
The reason these drugs
require a prescription is that they are powerful medications," says Wilson Compton, MD, director of the Division of Epidemiology, Services and Prevention Research, at the National Institute on Drug
Heartburn, on the other hand, is; but, unfortunately for Glaxo, most people considered heartburn nothing more than one of the wages of overindulgence, treatable with an over-the-counter remedy or a little more self-control at the dinner table--not with a prescription drug