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Outbreak of W135 meningococcal disease in 2000: not emergence of a new W135 strain but clonal expansion within the electrophoretic type-37 complex. Seborrheic keratosis is considered to represent a clonal expansion, so the lesion qualifies as a neoplasm. One hypothesis is that HCV Ab complexes may lead to clonal expansion of Blymphocytes within the liver, which have been shown to produce rheumatoid factor (RF) and recognize HCV epitopes. |
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