Lesions Which May Be Associated With Hyperthyroidism Nonneoplastic parathyroid lesions Parathyroid hyperplasia Primary chief cell
hyperplasia Water-clear cell hyperplasia Parathyroiditis Parathyroidal cysts Neoplasms of the parathyroid glands Adenoma Atypical adenoma Lipoadenoma Carcinoma Secondary neoplasms Metastases Invasion of tumors by direct extension Table 2.
Results of subtotal parathyroidectomy for primary chief cell
The chief cells
also appear normal and occupy about a quadrant of the gastric mucosa.
The chief cells
are distorted and shrunken and due to shrinkage, the pericellular spaces around these cells are very much increased.
Recently, the applicant identified Troy+ chief cells
as a novel stem cell population in the corpus epithelium.
Neoplastic chief cells
are usually positive for neuroendocrine markers, such as chromogranin A, synaptophysin, and neuron-specific enolase, but are negative for cytokeratins, CAM 5.
Oxyphil cells were also seen as placed singly among chief cells
(fig no 8) or as continuous masses or anastomosing columns (fig no 3).
We already knew that these cells, which are called chief cells
, can change back into stem cells to make temporary repairs in significant stomach injuries, such as a cut or damage from infection," Jason Mills, MD, PhD, associate professor of medicine at Washington University said.
When chief cells
in our parathyroid glands sense that calcium in our blood is too low, parathyroid hormone is released, resulting in an increase of serum calcium through multiple means: receptor-mediated tubular reabsorption of calcium in the kidney, release of skeletal calcium stores, upregulation of 1-a-hydroxylase leading to increased 1,25-d hyd roxy-yitamin D production, and increased calcium reabsorption from the gastrointestinal tract
were intensely positive for neuro-endocrine markers such as chromogranin A (Figure 2B), synaptophysin.