half-life

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Half-life

Half Life

In a pool of mortgages underlying a mortgage-backed security, the length of time it takes for half the aggregate principal to be repaid. A half life is normally about 12 years, but this may vary depending on how often homeowners refinance their mortgages (which pays off all principal at once). Half lives are calculated for mortgage-backed securities issued or guaranteed by Freddie Mac, Fannie Mae, and Ginnie Mae.

Weighted Average Life

The amount of time for the principal on a loan or a mortgage to be paid off. The length of the weighted average life depends on the amount of principal paydowns and how often they are made. Once the WAL is calculated, one can determine how long it will take to pay off half of the remaining principal.

half-life

The length of time before half the principal on a debt is expected to be repaid through amortization or sinking fund payments. For example, a 25-year bond issue may require the issuer to retire 5% of the beginning principal commencing 5 years after the issue date. Thus, the bond issue has a half-life of 5 years plus the number of years required to retire half the issue, or 15 years. Mortgage-backed securities often have a relatively short half-life because many homeowners pay off or refinance their mortgages early. Also called average life.
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Although only 3 infants had detectable antibody titers at 6 months of age, our study estimates the biological half-life of EV71 maternal antibodies to be 42 days, similar to the half-lives of antibodies to other pathogens calculated by using longitudinal analysis (1; M.
However, in certain indications, some of their features can be detrimental: stimulation of the immune system via the antibody effector region; bivalent binding or crosslinking of the antigen; or the antibodies long biological half-life.
PolyXen is designed to improve the stability, biological half-life and immunologic characteristics of therapeutic proteins naturally.
Delayed drug absorption due to altered gastric emptying can result in therapeutic failure, especially if the drug has a short biological half-life.