At present, both European and American guidelines advise the use of beta-blockers
for symptomatic heart failure without regard to AF status, based on trials that predominantly enrolled patients in sinus rhythm.
have a more general action and block shaking and sweating.
We calculated a priori that to observe a 50% increase in effective perioperative beta-blocker
therapy in patients prescribed perioperative betablockers from 40% to >60% or a 50% decrease from 40% to <20%, we needed 260 patients in each cohort (type I error 0.
Although patients on beta-blockers
in this study were older and more severely injured than were those not taking beta-blockers
, mortality rates for the two groups were similar, Dr.
have been used for more than 30 years to treat hypertension, cardiac arrhythmias, and migraine headaches, OsteoCorp is optimizing them as a new class of bone-building drug with broad therapeutic applications to prevent and treat osteoporosis and other diseases of bone," said Charles S.
We know these drugs can save lives, so we need to conduct more research to determine why the prescribing rate of beta-blockers
for heart failure is exceptionally low in the UK.
are certainly necessary in many patients who have coronary artery disease; however, an attempt should be made to adjust the dosage to allow attainment of at least 70% predicated maximal heart rate or keep heart rate levels below that which cause ST depression or angina.
While the New York Heart Association functional class was similar in both groups, patients taking beta-blockers
had lower heart rates compared with those receiving beta-blocker
therapy (mean 68 beats/minute versus 76 beats/minute.
The investigators believe that all patients scheduled to undergo bypass surgery--except for those whose hearts are severely weakened--should receive beta-blocker
therapy before surgery.
drugs indefinitely on heart attack survivors and people whose hearts are getting an inadequate blood supply.
The findings of the Beta-Blocker
Evaluation of Survival Trial (BEST), which contrast with those of other beta-blocker
studies, appear in the May 31 issue of the New England Journal of Medicine.
Moser states, this is the only trial in which a beta-blocker
arm was compared against a diuretic arm and against placebo.