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Half-Life
(redirected from antibody half-life)

   Also found in: Dictionary/thesaurus, Medical, Encyclopedia, Wikipedia 0.01 sec.
Half-life

Half Life
In a pool of mortgages underlying a mortgage-backed security, the length of time it takes for half the aggregate principal to be repaid. A half life is normally about 12 years, but this may vary depending on how often homeowners refinance their mortgages (which pays off all principal at once). Half lives are calculated for mortgage-backed securities issued or guaranteed by Freddie Mac, Fannie Mae, and Ginnie Mae.

Weighted Average Life
The amount of time for the principal on a loan or a mortgage to be paid off. The length of the weighted average life depends on the amount of principal paydowns and how often they are made. Once the WAL is calculated, one can determine how long it will take to pay off half of the remaining principal.

half-life
The length of time before half the principal on a debt is expected to be repaid through amortization or sinking fund payments. For example, a 25-year bond issue may require the issuer to retire 5% of the beginning principal commencing 5 years after the issue date. Thus, the bond issue has a half-life of 5 years plus the number of years required to retire half the issue, or 15 years. Mortgage-backed securities often have a relatively short half-life because many homeowners pay off or refinance their mortgages early. Also called average life.


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involving its Xtend[TM] antibody half-life prolongation technology, in which Xencor has granted Merck an exclusive license to its Xtend[TM] technology for the development of antibodies towards an undisclosed Merck drug target.
Pfizer will apply Xencor's proprietary Xtend[TM] antibody half-life prolongation technology and XmAb[R] ADCC enhancing technology to its antibody drug candidates.
The Company's growing library consists of over 2,000 Fc variants that have been engineered for select amino acid changes to provide a wide range of immunological properties and increased antibody half-life.
 
 
 
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