Serotonin (95% of the neurotransmitters found in GI tract) can stimulate cholinergic neurons to release acetylcholine
which results in smooth muscle contraction.
Characterization of the nicotinic acetylcholine
receptor subunit gene Mda2 from the house fly, Musca domestica.
to give a fresh, more creative approach to problem solving.
Six neuroactive compounds, acetylcholine
chloride (Wako Pure Chemical Industries, Ltd), serotonin creatinine sulfate (Wako), epinephrine bitartrate (Research Biochemicals Inc.
In these healthy subjects, the vasodilator response to intracoronary infusion of acetylcholine
at both the epicardial and the microvascular levels of coronary circulation was significantly attenuated by L-NMMA (Fig.
The paper, titled "EVP-6124, a novel and selective a7 nicotinic acetylcholine
receptor partial agonist, improves memory performance by potentiating the acetylcholine
response of a7 nicotinic acetylcholine
receptors," is available online at http://www.
affects the release of other neurotransmitters such as norepinephrine.
Researchers noticed that if a signal occurred after a long period of monitoring or "non-signal" processing, there was a spike in acetylcholine
in the rat's right prefrontal cortex.
Regarding neurotropic effects, in addition to that of acetylcholine
(neurotropic effect: as was performed in this study), histamine (antiallergic effect) and possibly serotonin as neurotransmitter should be included.
ASM-024 utilizes Asmacure's proprietary technology comprised of nicotinic acetylcholine
receptor agonists and is the first nicotinic receptor agonist in the clinic for this indication.
These agents produce this effect at the neuromuscular junction by interfering with the action of the neurotransmitter acetylcholine
Tacrine works by blocking the breakdown of acetylcholine