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SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci.

Evaluation of ADAM33 gene's single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Linkage disequilibrium analysis: Linkage disequilibrium (LD) analysis, defined by the delta coefficient (D'), was estimated in both case and control groups for the 5 SNPs of ER-[beta] rs3020449C/T, rs3020450 G/A, rs1271572G/T in rs1256049G/A and rs4986938G/A.

Impact of Genetic Variants in Estrogen Receptor-[beta] Gene in the Etiology of Uterine Leiomyomas

Linkage disequilibrium: The LD between SNP pairs was used to calculate the standardized LD value D' [19] and [r.sup.2] [20].

Analysis of genetic characteristics of pig breeds using information on single nucleotide polymorphisms

Pairwise comparisons for multiple tests among the polymorphic loci showed significant linkage disequilibrium between loci (Table 3), while 8 loci showed significant evidence for the presence of null alleles (Cxan2, Cxan5, Cxan6, Cxan10,Cxan13, Cxan16, Cxan27, Cxan28) according to Bonferroni correction (p [less than or equal to] 0.05), which can indicate homozygosis excess.

Development and characterization of microsatellite loci for Campomanesia xanthocarpa (Myrtaceae) and cross amplification in related species

Significant linkage disequilibrium was not detected between any pair of loci with a Bonferroni correction for multiple comparisons.

CHARACTERIZATION OF NOVEL EST-SSR IN THE CLAM MERETRIX PETECHIALIS AND CROSS-SPECIES AMPLIFICATION IN THREE OTHER SPECIES

Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NATI* 10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NATI and NAT2.

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis

The results of current study showing 10.3% of BD and 33.3% of AS patients with high ACTH-stimulated 17-OH-P levels warrant further analysis to screen CYP21A2 mutations in linkage disequilibrium with HLA-B51 and HLA-B27 by genetic methods, to confirm their role in the development of male predominant disorders.

THE ROLE OF 21-HYDROXYLASE DEFICIENCY IN THE PATHOGENESIS OF BEHCET DISEASE / BEHCET HASTALIGI PATOGENEZINDE 21-HIDROKSILAZ EKSIKLIGININ ROLU

Interestingly, rs46522 was at strong linkage disequilibrium with rs2291725 in the Chinese Han population, which could be interpreted that the rs2291725 in GIP gene could affect genetic susceptibility to CAD in the population.

Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes

Due to the absolute linkage disequilibrium between rs9263726 and the HLA-B* 58:01 allele found in 27 Japanese patients who suffered from allopurinol-induced SCARs, the rs9263726 has been proposed as a surrogate marker for allopurinol-induced SJS/TEN [18].

Comparison between the HLA-B*58:01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

Also, linkage disequilibrium can imply that variants in genes in close proximity to each other may segregate (travel together) during recombination or random assortment.

Partitioning the Genetic Architecture of Plasma Lipoprotein(a) and Kringle IV Type 2 Repeats: Implications for Therapeutic Lowering