No significant difference was found between the two groups in the primary
end point and the secondary
end point at 2-year follow-up.
Given that MeHg and PUFA operate largely in different directions on the same
end points, the analysis of data on risk and/or on the benefit offish consumption to derive practical fish consumption advisories is not straightforward.
By its very nature, physiotherapy intervention requires active participation on the part of the patient, and this fact calls for a more energetic role by the patient in decision-making about the
end point of therapy.
The marked reduction in clinical
end points in ASCOT was evident during the first year on atorvastatin and was unrelated to baseline cholesterol level.
The primary
end point for efficacy was central subfield retinal thickness as measured by Optical Coherence Tomography (OCT) and reported in microns.
Ampio Pharmaceuticals Inc (Nasdaq: AMPE), a clinical stage biopharmaceutical company, whose lead drugs treat inflammatory diseases, including osteoarthritis and complications of Diabetes Mellitus such as diabetic macular edema, has announced today that it's CRO has completed analysis of the primary
end point in the Optina(tm) clinical trial for Diabetic Macular Edema.
The primary
end point was met by 16% and 21.3% of patients in the 145-mcg and 290-mcg linaclotide groups, compared with 6.0% in the placebo group.
In the first trial (Trial 303), 21.2% and 19.4% of patients on the 145-mcg and 290-mcg doses, respectively, achieved the primary
end point of three or more complete spontaneous bowel movements (CSBMs) per week plus an increase of one or more CSBMs per week over baseline during at least 9 of the 12 study weeks.
Those on AZLI also had improvements in [FEV.sub.1], a secondary
end point; these improvements were significantly greater than they were in those on placebo.