Compounds involved in the
citric acid cycle and pyruvate metabolism were decreased in the postmortem aging period (adjusted p<0.05, FDR<0.10) (Table 3).
Essential intermediate between Krebs
citric acid cycleThe
citric acid cycle is then blocked at the level of isocitrate, which accumulates and is balanced with the citrate action of aconitase.
For example, another interesting potential application of metabolomic studies of carbohydrate metabolism to alcohol research is based on observations suggesting that breakdown products of glucose that are generated during the
citric acid cycle (see sidebar figure, p.
Fermentation provides sufficient energy but lacks the intermediates necessary for the
citric acid cycle to synthesize cellular components such as succinate.
Wachtershauser focuses on the heart of modern metabolism, the
citric acid cycle. All living cells use this series of reactions to extract energy from food.
Succinic, malic, and citric acids are all derived from either plant or microbial intermediates of the
citric acid cycle and it is interesting that only succinic acid was found in soil solutions under the LL rotation.