It also indicates that to make the evaluation possible, the dietary exposures on the dietary-exposed day also need to be large; the biologic half-life of the chemical, [T.sub.1/2], needs to be short because k is proportional to 1/[T.sub.1/2]; and a substantial fraction of the metabolites should be eliminated through the urinary pathway.
Equations for calculating [R.sub.inhalation], [R.sub.nondietary], and [P.sub.dietary] were keyed in, and variables of interest, such as biologic half-life, dust loading, air concentration, and nondietary intake, were set in such a way that they could be easily varied to conduct the simulation.
Urinary measurements and biologic half-life. Figure 3 shows the urinary metabolite measurements in overnight voids as point estimates (when the urine samples are collected at 0800 hr) after three exposed-day/nonexposed-day pairs with various lengths of biologic half-life of the selected chemical.